Provox Life evidence Ward

New clinical study demonstrates significant improvement in pulmonary health and related symptoms when using Provox Life

A new multi-center, prospective, two-phase clinical trial¹ supported by Atos Medical, a leading company in laryngectomy care, demonstrates a significant improvement in cough and sputum symptoms leading to improved sleep with Provox Life.

In 2020, Atos Medical launched an entire new range of heat and moisture exchangers (HMEs) and adhesives, aimed at improving pulmonary health and quality of life for people living with a laryngectomy. A growing body of evidence has shown that the superior humidification and breathability of Provox Life HMEs lead to improved clinical outcomes.

People who have undergone a total laryngectomy rely on HMEs to compensate for the lack of upper airway humidification and filtration. With legacy HMEs, many laryngectomized patients use one type of HME throughout the day irrespective of activity levels.

The objectives of the new clinical study were to examine changes in pulmonary and related symptoms using a new generation of Provox Life HMEs. The study was a two-phase clinical trial starting with the transition to comparable Provox Life HMEs and usage patterns (stage one). In the second stage, patients used different types of HMEs based on the activity, aiming for the highest possible humification for day and night. The following results were reported:

• During stage one, transitioning to the higher performing Provox Life HMEs significantly improved overall pulmonary health
• During stage two, using the highest humidification HMEs optimally during the day and night further improved pulmonary health
• Quality of sleep only improved significantly when Provox Life HMEs were used throughout the day and night
• Using the new generation of Provox Life HMEs enhanced HME adherence and 4. facilitated the use of an optimal day and night regimen

The research confirms the potential to improve pulmonary health and related symptoms for laryngectomized patients by using better performing HMEs. There is also a potential to increase the number of hours HMEs are used per day when using a range of devices with different breathing resistance levels that suit the activity.

Learn more about the new clinical study.

[1] Elizabeth C Ward, Kelli Hancock, Jenni Boxall, Clare L. Burns, Ann-Louise Spurgin, Belinda Lehn,4 Juliet Hoey,4 Rachelle Robinson,5 and Adele Coleman: Post-laryngectomy pulmonary and related symptom changes following the adoption of an optimal Day-and-Night Heat and Moisture Exchange (HME) regimen. First published 20 February 2023, https://doi.org/10.1002/hed.27323